A heavyweight bout between former UFC Heavyweight Championship challenger Derrick Lewis and Sergey Spivak was expected to headline the event. However, while the event was in progress, Lewis was forced to withdraw due to non-COVID, non-weight cutting illness and the bout was cancelled. As a result, Kennedy Nzechukwu and Ion Cuțelaba instead headlined the event. Kennedy Nzechukwu vs. Ion Cuțelaba (Light Heavyweight) Chase Sherman vs. Waldo Cortes-Acosta (Heavyweight) André Fialho vs. Muslim Salikhov (Welterweight) Jack Della Maddalena vs. Danny Roberts (Welterweight) Charles Johnson vs. Zhalgas Zhumagulov (Flyweight)
