After her ex-convict husband Bill is killed in a bank robbery, Nancy Preston and her young son Bubsy are protected by Mike Horgan, a former friend from Sing Sing. Mike is wrongfully jailed, and Nancy—falsely accused of murdering a criminal fence who tried to abuse her—goes on the run. Mike breaks out of prison to join Nancy in a small town where he practices medicine under his real name, Stafford. When a persistent detective tracks them down, he falls ill, gets nursed back to health by the pair, has a change of heart, and proves Nancy's innocence so she and Mike can marry.
